Tune Deafness: Processing Melodic Errors Outside of Conscious Awareness as Reflected by Components of the Auditory ERP
Identifieur interne : 000F85 ( Main/Exploration ); précédent : 000F84; suivant : 000F86Tune Deafness: Processing Melodic Errors Outside of Conscious Awareness as Reflected by Components of the Auditory ERP
Auteurs : Allen Braun [États-Unis] ; Joe Mcardle [États-Unis] ; Jennifer Jones [États-Unis] ; Vladimir Nechaev [États-Unis] ; Christopher Zalewski [États-Unis] ; Carmen Brewer [États-Unis] ; Dennis Drayna [États-Unis]Source :
- PLoS ONE ; 2008.
Abstract
Tune deafness (TD) is a central auditory processing disorder characterized by the inability to discriminate pitch, reproduce melodies or to recognize deviations in melodic structure, in spite of normal hearing. The cause of the disorder is unknown. To identify a pathophysiological marker, we ascertained a group of severely affected TD patients using the Distorted Tunes Test, an ecologically valid task with a longstanding history, and used electrophysiological methods to characterize the brain's responses to correct and incorrect melodic sequences. As expected, we identified a neural correlate of patients' unawareness of melodic distortions: deviant notes modulated long-latency auditory evoked potentials and elicited a mismatch negativity in controls but not in affected subjects. However a robust P300 was elicited by deviant notes, suggesting that, as in blindsight, TD subjects process stimuli that they cannot consciously perceive. Given the high heritability of TD, these patients may make it possible to use genetic methods to study cellular and molecular mechanisms underlying conscious awareness.
Url:
DOI: 10.1371/journal.pone.0002349
PubMed: 18545651
PubMed Central: 2396485
Affiliations:
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The cause of the disorder is unknown. To identify a pathophysiological marker, we ascertained a group of severely affected TD patients using the Distorted Tunes Test, an ecologically valid task with a longstanding history, and used electrophysiological methods to characterize the brain's responses to correct and incorrect melodic sequences. As expected, we identified a neural correlate of patients' unawareness of melodic distortions: deviant notes modulated long-latency auditory evoked potentials and elicited a mismatch negativity in controls but not in affected subjects. However a robust P300 was elicited by deviant notes, suggesting that, as in blindsight, TD subjects process stimuli that they cannot consciously perceive. Given the high heritability of TD, these patients may make it possible to use genetic methods to study cellular and molecular mechanisms underlying conscious awareness.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Braun, Allen" sort="Braun, Allen" uniqKey="Braun A" first="Allen" last="Braun">Allen Braun</name></region><name sortKey="Brewer, Carmen" sort="Brewer, Carmen" uniqKey="Brewer C" first="Carmen" last="Brewer">Carmen Brewer</name><name sortKey="Drayna, Dennis" sort="Drayna, Dennis" uniqKey="Drayna D" first="Dennis" last="Drayna">Dennis Drayna</name><name sortKey="Jones, Jennifer" sort="Jones, Jennifer" uniqKey="Jones J" first="Jennifer" last="Jones">Jennifer Jones</name><name sortKey="Mcardle, Joe" sort="Mcardle, Joe" uniqKey="Mcardle J" first="Joe" last="Mcardle">Joe Mcardle</name><name sortKey="Nechaev, Vladimir" sort="Nechaev, Vladimir" uniqKey="Nechaev V" first="Vladimir" last="Nechaev">Vladimir Nechaev</name><name sortKey="Zalewski, Christopher" sort="Zalewski, Christopher" uniqKey="Zalewski C" first="Christopher" last="Zalewski">Christopher Zalewski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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